Nick Bosa Missed 49ers Practice With Injury
The San Francisco 49ers star defensive end was held out of Thursday session due to knee and calf issues.
Updated on Sept. 25, 2026 in Football
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San Francisco 49ers defensive end Nick Bosa sat out of team practice on Thursday in Santa Clara. The team updated his official status to reflect both knee and calf injury designations.
Why it matters
Bosa serves as a critical component of the 49ers defensive front, making his participation status a significant factor for the team's upcoming defensive performance. His absence highlights concerns regarding durability as the team manages his physical load through the early season.
Nick Bosa has logged 69 snaps over the first two weeks of play, recording six total pressures. This includes a performance of five pressures recorded during the Week 2 matchup.
The players
Nick Bosa
He is an elite defensive end for the San Francisco 49ers known for his high pressure rate on opposing quarterbacks.
San Francisco 49ers
The team is a professional football organization based in the San Francisco Bay Area that competes in the National Football League.
Mike Evans
He is a wide receiver in the National Football League who was also held out of his team's Thursday practice due to a hip injury.
The details
The 49ers updated the injury report on Thursday to include the calf designation alongside his knee issue after Bosa rested during the Wednesday session. Bosa, 28, has historically managed significant injury setbacks throughout his professional career.
Timeline
Nick Bosa rested during practice on Wednesday.
The 49ers defensive end was absent from the Thursday practice session.
Season Trajectory
This injury report update could alter the defensive rotation and pressure efficiency for the 49ers as they attempt to maintain their competitive standing in the division. Managing Bosa's health is critical to the team's ability to maintain high defensive output throughout the long season.
Bosa's absence complicates the defensive pass rush plan for the upcoming game and may shift snap counts to other members of the defensive line. Fantasy managers and observers should monitor the final injury report for his official game-day status.
The takeaway
Maintaining the health of star players like Bosa remains a constant priority for NFL coaching staffs during the grueling regular season. Fans should look for final active/inactive lists released ninety minutes before kickoff to confirm his participation.
Further reading
For more news regarding team rosters and injury updates, visit the Football section.
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