EFSA Validates L-Threonine Additive Safety for Animals
Regulators confirm the feed additive remains safe but note potential risks associated with water-based administration.
Updated on Oct. 20, 2026 in Life Sciences
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The European Food Safety Authority's FEEDAP Panel has approved the renewal of L-threonine as a feed additive for target animals. While findings indicate the substance is safe for consumers and the environment, experts raised specific concerns about hygienic issues in drinking water.
Why it matters
The panel reviewed the additive, which is produced via a genetically modified strain of E. coli, to ensure continued compliance with European food safety standards. The potential for nutritional imbalances when amino acids are delivered through water remains a key area of caution for industry regulators.
The additive maintains a minimum of 98% L-threonine purity on a dry matter basis. Analysts also noted a recommended occupational exposure limit of 90 EU/m3 for endotoxins.
The players
EFSA FEEDAP Panel
This body provides scientific advice on additives and products used in animal feed within the European Union.
E. coli CGMCC 7.58
This is a specific genetically modified strain of bacteria used in the fermentation production of the L-threonine additive.
The details
The additive is created through fermentation using the genetically modified E. coli strain CGMCC 7.58, which contains no acquired antimicrobial resistance genes. Verification tests, including PCR analysis, confirmed that no viable cells or DNA from the production strain remain in the final product.
Timeline
October 2025: The applicant performed a comprehensive literature search regarding additive safety.
The Big Picture
This assessment follows the established requirements of the European Union's feed additive authorization regulations. The decision reflects the ongoing regulatory pattern for the mandatory periodic renewal of additives used in agricultural supply chains.
The renewal ensures that the supply chain for this essential amino acid additive remains compliant with safety standards. Farmers and feed producers can continue to utilize the product while addressing the panel concerns regarding water-based delivery methods.
The takeaway
Producers should monitor delivery methods, as even safe additives can introduce risks when added to livestock water systems. Maintaining high production standards remains the primary defense against potential nutritional or hygienic complications in animal feed.
Further reading
For more information on regulatory science, visit the Life Sciences section.
More information
View the complete EFSA scientific opinion document.
Source note: This article includes information reported by EFSA.
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