Marigold Flower Extract Repelled Ticks in Study
Researchers developed a new topical cream using Tagetes erecta to combat tick infestations.
Updated on Sept. 26, 2026 in Botany
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Scientists have developed a topical cream using Tagetes erecta flower extracts that demonstrated significant effectiveness against Haemaphysalis bispinosa ticks. The plant-based formula achieved high repellency rates in both larval and adult tick populations.
Why it matters
Conventional synthetic acaricides are becoming less effective due to rising tick resistance, and this research offers a potential botanical alternative to manage tick-borne threats while addressing environmental concerns.
The extract achieved 61.56% acetylcholinesterase inhibition at 1000 µg/mL with an estimated IC₅₀ of 267.6 µg/mL. Computational docking identified Nonylamine N, N-di(allyl) as the most potent constituent with a docking energy of -9.29 kcal/mol.
The players
Haemaphysalis bispinosa
This species of tick is a significant parasite that researchers used to evaluate the efficacy of the new floral extract.
Tagetes erecta
Commonly known as the African marigold, this plant was the primary source for the bioactive extracts tested in the study.
The details
Researchers tested the cream using three independent biological replicates over 6 hours, finding that specific constituents like Yangambin interact with tick salivary protein BSAP1. Molecular dynamics simulations confirmed the stability of this complex over a 100 ns duration.
Timeline
Repellency against larval and adult ticks was observed during a 6-h observation period.
Molecular dynamics simulation of the protein-ligand complex lasted 100 ns.
The Big Picture
This discovery extends the current research into botanical acaricides as a sustainable alternative to traditional chemical treatments. By mapping the interaction between plant-based compounds and tick proteins, the study provides a new framework for developing eco-friendly pest control.
If successfully commercialized, this research could lead to safer, plant-based tick repellents that reduce reliance on synthetic chemicals for humans and animals. These findings may eventually result in new consumer products that are less harsh while maintaining high efficacy against tick bites.
The takeaway
Botanical alternatives like marigold extract show promise as effective, environmentally friendly tools for tick management. Future studies will need to move beyond computer models to confirm the functional benefits of these natural compounds in real-world environments.
Further reading
Learn more about the latest developments in plant-based science in our Botany section.
More information
Read the complete peer-reviewed research article for detailed methodology.
Source note: This article includes information reported by Nature.
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