NYU Langone Integrates Clinical AI into Epic System

The health system has embedded the OpenEvidence platform into its electronic records to assist physicians with patient queries.

Updated on Oct. 29, 2026 in Artificial Intelligence

Bold flat-color editorial illustration depicting a sculptural hospital light fixture, reflecting the integration of AI into clinical health infrastructure. — NYU Langone Health has integrated the OpenEvidence AI platform into its Epic electronic health record system to support over 6,000 clinicians. AI Illustration. Upload story photo >

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NYU Langone Health has integrated the OpenEvidence clinical AI platform directly into its Epic electronic health record system. The tool utilizes agentic AI to synthesize patient records with the latest medical literature for clinicians across its hospitals and ambulatory network.

Why it matters

This integration aims to provide clinicians with safe, practical access to medical evidence at scale by embedding AI directly into their existing digital workflows. It represents a significant effort to streamline how physicians retrieve information during patient care.

The OpenEvidence platform integrates directly into Epic workflows to support natural language queries. As of October 2026, verified U.S. clinicians utilized the platform for 45 million queries, following a period where nearly 1 million users submitted 271 million queries.

The players

NYU Langone Health

This academic medical center operates a comprehensive network of hospitals and outpatient facilities in New York City.

OpenEvidence

This platform provides a clinical AI solution designed to assist healthcare professionals in accessing and synthesizing medical literature.

Epic

This organization develops the electronic health record software used by hospitals and clinics to manage patient data.

The details

The rollout spans NYU Langone's extensive network, which manages 12 million outpatient visits and 421,000 emergency department visits annually. More than 6,000 physicians and faculty members now have access to the agentic AI tool within their daily electronic record interface.

From January 2024 to June 2026, clinicians submitted 271 million queries via OpenEvidence.
During October 2026, verified U.S. clinicians used the platform for 45 million queries.

The Tech Race

The integration of agentic AI into the Epic electronic health record system signals a shift toward embedding specialized research assistants into core hospital infrastructure. This replaces traditional, manual literature review processes with real-time, record-integrated computational synthesis.

Physicians and faculty at NYU Langone will now have AI-driven support available within their patient records for daily clinical decision-making. This technology is intended to streamline information retrieval, potentially reducing the time required to search for evidence during patient interactions.

The takeaway

Clinical AI integration is rapidly evolving from stand-alone tools to deeply embedded systems within hospital record software. Physicians can implement these platforms by leveraging existing natural language query interfaces to access medical literature more efficiently.