Emory University Launched Alzheimer's Research Trial
The clinical trial evaluates if the drug baricitinib improves cognitive symptoms in former football players.
Updated on Sept. 19, 2026 in Alzheimer’s
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The Concussion & CTE Foundation and Emory University School of Medicine launched a clinical trial in August 2026 to study baricitinib. The research aims to see if the once-a-day pill can improve cognitive symptoms and depression in former players.
Why it matters
Researchers hypothesize that reducing brain inflammation to normal levels could potentially improve symptoms associated with chronic traumatic encephalopathy (CTE) and other brain diseases. This study represents a significant effort to address the long-term neurological health of retired athletes.
The clinical trial recruits adult men aged 30-55 who have at least 11 years of tackle football experience. Baricitinib is an FDA-approved anti-inflammatory medication, but its specific impact on brain disease is currently under investigation.
The players
Emory University School of Medicine
This institution is a prominent medical school that conducts extensive clinical research and is the site for this specific brain health trial.
Concussion & CTE Foundation
This organization advocates for the research and understanding of brain trauma related to contact sports.
Casey Toohill
A retired NFL player who recently joined the advisory board of the Concussion & CTE Foundation.
The details
The study evaluates whether baricitinib, a medication typically used to treat inflammation, can mitigate cognitive decline. Former NFL player Casey Toohill, who retired after a six-year career, joined the Concussion & CTE Foundation advisory board to support such initiatives.
Timeline
Casey Toohill joined the advisory board in August 2026.
The clinical trial launch was publicized in September 2026.
The Big Picture
This clinical trial aligns with the ongoing research programs of the Concussion & CTE Foundation to understand long-term brain health in athletes. It marks an effort to bridge the gap between inflammation management and neurodegenerative symptom treatment.
The trial directly impacts the potential treatment options for retired athletes experiencing cognitive decline. Participants must meet specific age and football experience criteria to qualify for this intervention.
The takeaway
This study highlights the growing scientific focus on mitigating chronic brain inflammation in former athletes. It provides a new avenue for research into conditions that currently can only be formally diagnosed after death.
Further reading
Learn more about advancements in neurological research on the Alzheimer’s section of our site.
Live Poll
Should medical research prioritize treating the long-term health effects of high-impact sports?
