Highway 101 Southbound Closes for Weekend Repaving
Caltrans will shut all four southbound lanes through San Francisco's Mission District from Friday night to Monday morning.
Updated on Nov. 5, 2026 in Home Renovation
Caltrans will close all four southbound lanes of Highway 101 in San Francisco's Mission District starting at 11 p.m. Friday, Nov. 6, reopening at 6 a.m. Monday, Nov. 9, for repaving work. Drivers will lose access to on-ramps at Fourth, Seventh and 10th streets, and the connector from westbound Interstate 80 to Highway 101 north.
Why it matters
The closure is part of the Hospital Curve overhaul, which aims to extend the useful life of a 70-year-old freeway segment. Residents and commuters in the Mission and SoMa should plan alternate routes for the full weekend.
The construction zone runs from 17th Street to Cesar Chavez Street, and the closure lasts about 55 hours over the weekend. The freeway segment is 70 years old, and the Hospital Curve overhaul is set to continue through 2028.
The players
Caltrans
The California Department of Transportation is the state agency responsible for maintaining and rehabilitating the state highway system, including Highway 101 in San Francisco.
The details
Caltrans has published a map diverting southbound motorists onto Interstate 280 or down Harrison Street and Potrero Avenue, with detours starting at Fifth Street in SoMa. The work includes drainage repair, layers of fresh concrete and a new median barrier along the curve.
Timeline
11 p.m. Friday, Nov. 6: Southbound closure begins
6 a.m. Monday, Nov. 9: Southbound lanes scheduled to reopen
2028: Hospital Curve overhaul expected to be complete
Seasonal Patterns
The closure is the latest phase of Caltrans' multi-year Hospital Curve rehabilitation, which is scheduled to run through 2028. Work is being staged in weekend windows to limit disruption as the 70-year-old freeway segment is rebuilt piece by piece.
Drivers heading south through the Mission should use Interstate 280 or Harrison Street and Potrero Avenue during the weekend closure. Commuters who rely on the Fourth, Seventh and 10th street on-ramps will need to find another way onto the freeway until Monday morning.
The takeaway
Plan weekend trips through the Mission well ahead, since the Hospital Curve work will keep returning in phases until 2028. Checking Caltrans' detour map before leaving can save time on the southbound route.
What happens next
Southbound Highway 101 is scheduled to reopen at 6 a.m. Monday, Nov. 9, and the Hospital Curve overhaul is set to continue through 2028.
Further reading
For more on home and property projects, see Home Renovation coverage.
