Nick Bosa Sustained Calf Injury in Practice
The 49ers defensive star may miss several weeks, including the upcoming Week 5 matchup against the Seattle Seahawks.
Updated on Sept. 25, 2026 in Football
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San Francisco 49ers standout Nick Bosa suffered a calf injury during Thursday's practice session. The veteran defender is expected to miss multiple weeks and could potentially be sidelined until Week 7.
Why it matters
Bosa's injury significantly impacts San Francisco's defensive depth, as the team is already managing a high number of injuries among its primary defensive front seven.
There are currently six members of the defensive front seven on injured reserve, including five defensive linemen. The injured linemen currently on the list are C.J. West, Sam Okuayinonu, Mikail Kamara, Andrew Famer II, and Alfred Collins.
The players
Nick Bosa
He is a star defensive end for the San Francisco 49ers known for his elite pass-rushing abilities.
San Francisco 49ers
They are a professional football franchise based in the San Francisco Bay Area competing in the NFC West.
The details
Nick Bosa sustained the calf injury during a routine practice session on Thursday. The injury further depletes a defensive unit that has already seen significant personnel losses this season.
Timeline
Nick Bosa sustained a calf injury during a practice on Thursday.
San Francisco plays the Arizona Cardinals on Sunday.
The 49ers are scheduled to face the Seattle Seahawks in Week 5.
Bosa could remain out until at least Week 7 if placed on injured reserve.
San Francisco enters a scheduled bye week in Week 8.
The Big Picture
This injury management follows the NFL's Injured Reserve roster designation rules. The team must navigate these league-mandated recovery windows to maintain roster health throughout the season.
Bosa's absence forces a major rotation adjustment for the San Francisco defensive front in upcoming games. Fantasy managers and fans should monitor the team's depth chart as it adjusts to these personnel losses.
The takeaway
Team depth is currently being tested by a series of injuries across the defensive line. Coaches will likely rely on reserve players to fill the gap during this difficult stretch of the schedule.
Further reading
For more updates on team rosters and player health, see the latest Football news.
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