Broncos to Face Cardinals in Glendale on October 25

The Denver Broncos travel to face the Arizona Cardinals at State Farm Stadium this Friday afternoon.

Updated on Oct. 22, 2026 in Football

Broncos to Face Cardinals in Glendale on October 25

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After last week's win, are you more likely to support your local team this weekend?

The 4-2 Denver Broncos are set to play the 2-4 Arizona Cardinals in Glendale on October 25, 2026. Arizona enters the matchup hoping to break a nine-game home losing streak.

Why it matters

The Broncos arrive as 4.5-point favorites following an overtime win against the Seattle Seahawks, while the Cardinals look to build momentum after an 18-16 victory over the Los Angeles Rams. During the halftime festivities, the Cardinals will retire the number 11 jersey belonging to Larry Fitzgerald.

Bo Nix enters the game with 1,049 passing yards and a 60.3% completion rate. Defensively, Zach Allen has recorded 4.5 sacks over the first six games of the season.

The players

Bo Nix

He is the starting quarterback for the Denver Broncos who has accounted for six touchdowns this season.

Larry Fitzgerald

The legendary wide receiver will have his number 11 jersey retired by the Arizona Cardinals during the game.

Chad Ryland

He is a kicker for the Arizona Cardinals who successfully converted six field goals in the team's most recent win against the Los Angeles Rams.

Zach Allen

He is a defensive player for the Denver Broncos who was originally drafted by the Arizona Cardinals in 2019.

Paris Johnson Jr.

He is an offensive lineman for the Arizona Cardinals who will miss the remainder of the season due to a torn biceps injury.

The details

The Cardinals will be without offensive lineman Paris Johnson Jr., who sustained a season-ending torn left biceps in October 2026. Jayden Williams is slated to step into the left tackle position for Arizona while the Broncos defense attempts to replicate the pressure that resulted in 17 quarterback hits last week.

2019: Zach Allen is drafted by the Arizona Cardinals.
December 18, 2022: The Broncos and Cardinals last faced each other.
October 2026: Paris Johnson Jr. suffers a season-ending biceps tear.
October 25, 2026, 4:05 p.m. EDT: The Denver Broncos play the Arizona Cardinals in Glendale.

Season Trajectory

This game serves as a critical junction for the Arizona Cardinals, who are currently suffering through a nine-game home losing streak. A win against the favored Broncos would provide a significant boost to their standing within the league's competitive landscape.

The Denver Broncos are currently favored by 4.5 points in this contest. Fantasy managers should monitor the performance of Broncos quarterback Bo Nix, who has maintained a 60.3% completion rate this season.

The takeaway

This game highlights the ongoing roster adjustments for the Arizona Cardinals following the loss of Paris Johnson Jr. to injury. Fans should keep an eye on how the Cardinals' defensive line, led by Zach Allen, performs against the Denver Broncos' offense in front of a home crowd.