Transdermal Nitroglycerin Shows Mixed Hot Flash Results
A new systematic review evaluates the use of nitroglycerin patches for managing common menopausal symptoms.
Updated on Oct. 20, 2026 in Women’s Health
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Researchers have completed a systematic review of four studies regarding the use of transdermal nitroglycerin for treating menopausal hot flashes. The review examines potential nonhormonal alternatives for women who are unable or unwilling to use traditional hormone therapy.
Why it matters
Hot flashes affect up to 85% of menopausal women, with many reporting symptoms severe enough to impair daily life. Finding effective, nonhormonal treatments remains a priority for those who cannot utilize hormone therapy.
A systematic review of four studies involving 160 participants shows that while one single-arm trial saw a 69% reduction in hot flash frequency, most studies indicated minimal improvement versus a placebo. Additionally, early treatment headaches affected up to two-thirds of participants.
The players
The Menopause Society
This is a leading professional organization dedicated to promoting the health and quality of life of women during midlife and beyond.
University of Miami Miller School of Medicine
This academic institution is a prominent research center that conducts clinical studies on various health conditions.
The details
The review, conducted by researchers at the University of Miami Miller School of Medicine, analyzed the impact of continuous transdermal nitroglycerin on symptom frequency and quality of life. Findings suggest that symptoms often return once the nitroglycerin treatment is discontinued.
Timeline
October 20-24, 2026: The study results are presented at The Menopause Society 2026 Annual Meeting in San Diego.
Health Landscape
The study findings follow the evidence-based assessment patterns established by The Menopause Society clinical practice guidelines for vasomotor symptoms. This review adds to the ongoing scientific effort to evaluate nonhormonal therapeutic options within the broader field of menopause care.
Patients experiencing severe hot flashes should discuss nonhormonal options with their physician, keeping in mind the potential for common side effects like headaches. Since symptoms may return after stopping treatment, patients should focus on long-term management strategies rather than temporary relief.
The takeaway
While transdermal nitroglycerin has been explored, current data does not provide a definitive recommendation for widespread clinical use. Patients should prioritize consultations with healthcare providers to navigate the various treatment pathways available for menopausal symptoms.
Further reading
Learn more about the latest research and clinical standards in Women’s Health.
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Do you feel there are enough reliable non-hormonal treatment options available for managing menopause symptoms today?
