PrEP Use Reaches Record High in 2025
The number of people using HIV-prevention medication climbed to 644,170, though growth rates continue to slow.
Updated on Oct. 20, 2026 in Sexual Health
Live Poll
Is the nation doing enough to address barriers to accessing preventative HIV medications like PrEP?
In 2025, the number of individuals using PrEP for HIV prevention in the United States hit a record 644,170. This represents a 10% increase from 2024, marking the smallest annual growth observed in the past five years.
Why it matters
While PrEP reduces HIV transmission risk by 99% when taken as prescribed, persistent hurdles such as stigma, limited provider access, insurance challenges, and affordability issues continue to stifle broader adoption.
Nationwide PrEP use reached 644,170 individuals in 2025, reflecting a 10% annual increase. This medication reduces the risk of HIV transmission by 99% when taken correctly.
The players
AIDSVu
This organization tracks HIV prevalence and treatment data across the United States to assist public health researchers and policymakers.
The details
AIDSVu published these findings through a series of interactive maps and detailed state and county profiles to highlight the current landscape of HIV prevention. The data reveals significant demographic and geographic gaps, particularly in the South, which accounted for 39% of PrEP users despite representing 52% of new HIV diagnoses in 2024.
Timeline
2024 served as the reference period for tracking new HIV diagnoses.
2025 served as the reference period for the reported PrEP usage data.
October 19-25, 2026, is designated as PrEP Aware Week.
Health Landscape
The report provides a performance metric for the Centers for Disease Control and Prevention's Ending the HIV Epidemic in the U.S. initiative. This data update highlights the ongoing progress and persistent gaps in achieving the prevention goals set by the federal initiative.
Patients interested in HIV prevention should consult their healthcare provider to discuss whether PrEP is an appropriate and accessible option for their lifestyle. Individuals can use updated public profiles to identify regional trends in provider availability and insurance coverage.
The takeaway
Increased access to PrEP remains a critical tool for reducing HIV transmission rates across the country. Patients should prioritize consistent medical consultations to overcome logistical and financial barriers to obtaining the medication.
Further reading
For more on HIV prevention and treatment, explore the Sexual Health section.
More information
Access the comprehensive AIDSVu interactive PrEP data tool to view detailed state and county health profiles.
Source note: This article includes information reported by HOMBRE1.
Live Poll
Is the nation doing enough to address barriers to accessing preventative HIV medications like PrEP?
