Genetic Variant Linked to Heart Disease in African Ancestry

Researchers identified a CD36 variant that significantly increases the risk of dilated cardiomyopathy.

Updated on Oct. 20, 2026 in Heart Disease

A 3D genetic helix structure made of metal and glass stands in a sterile laboratory setting. — Researchers identified the CD36 Y325* genetic variant, which accounts for 9% of dilated cardiomyopathy cases in individuals of African ancestry. AI Illustration. Upload story photo >

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Scientists have discovered that the CD36 Y325* genetic variant is a major contributor to dilated cardiomyopathy in individuals of African ancestry. This specific variant is estimated to account for 9% of the disease burden within this population.

Why it matters

Previous research showed that African-ancestry participants had a 77% higher rate of developing dilated cardiomyopathy than European-ancestry participants, yet traditional gene panels often missed the cause. This finding addresses that diagnostic gap by identifying a variant rarely seen in European populations.

The CD36 Y325* variant is present in roughly 16% of individuals of African ancestry, while 0.77% carry two copies. Dilated cardiomyopathy affects approximately 1 in 250 people, with this variant accounting for 9% of cases in the studied population.

The players

Cleveland Clinic

This academic medical center is recognized globally for its extensive research programs and clinical expertise in cardiovascular health.

The details

Researchers analyzed genetic data from 82,623 people of African ancestry, identifying 1,316 individuals with dilated cardiomyopathy. The study compared the CD36 variant with protein-shortening variants in TTN and 11 other established cardiomyopathy genes to determine its unique impact on heart health.

A 2025 study highlighted a 77% higher rate of dilated cardiomyopathy in African-ancestry participants.

The Big Picture

This study follows the Million Veteran Program approach of leveraging large-scale longitudinal cohorts to identify genetic drivers of disease in diverse populations. By identifying this variant, researchers are bridging the gap in genetic understanding between different ancestral groups.

Identifying this variant could lead to more accurate genetic screening and diagnostic testing for individuals of African ancestry. Patients with a family history of heart disease may now have access to targeted genetic assessments to better manage their cardiovascular health.

The takeaway

This discovery demonstrates the importance of inclusive genomic research to ensure medical breakthroughs benefit all populations equally. Individuals with a family history of cardiomyopathy should consult their healthcare provider about the necessity of genetic testing.