OpenEvidence Has Secured $250 Million in New Funding

The AI-driven healthcare platform reached a valuation of $15 billion after a successful new investment round.

Updated on Sept. 28, 2026 in Healthcare

Bold flat-color editorial illustration of a stack of medical journals, navy and cream, representing evidence-based clinical research systems. — OpenEvidence secured $250 million in a new funding round, bringing the AI-driven healthcare platform's total valuation to $15 billion. AI Illustration. Upload story photo >

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OpenEvidence raised $250 million in a new funding round, bringing the company valuation to $15 billion. The platform currently serves more than half of all U.S. physicians through its AI-powered clinical research tools.

Why it matters

The investment underscores the growing integration of AI tools within medical practice, as the platform is now embedded into standard clinical workflows for major health systems. This influx of capital supports the continued expansion of tools used to provide evidence-based answers to medical questions.

The firm reached a $15 billion valuation, up from $12 billion in January 2026. OpenEvidence has now secured nearly $1 billion in total capital since it was founded in 2022.

The players

OpenEvidence

An AI-driven platform that provides medical professionals with answers grounded in peer-reviewed clinical studies.

Andreessen Horowitz

A prominent venture capital firm that specializes in investing in high-growth technology and software companies.

Byers Capital

A venture capital firm that participated in leading the latest funding round for the healthcare technology company.

Mount Sinai Health System

A large hospital network based in New York City that utilizes the platform within its clinical Epic workflows.

Sutter Health

A major not-for-profit health system based in Sacramento, California, that has integrated the platform into its operations.

The details

The company utilizes an AI search engine designed to pull answers directly from peer-reviewed medical studies and clinical guidelines. The platform is currently integrated into Epic health system workflows at major providers, including Mount Sinai Health System and Sutter Health.

OpenEvidence was founded in 2022.
The company raised $250 million in a series D round in January 2026.
The new $250 million funding round was confirmed in September 2026.

Market Landscape

This move reflects the ongoing arms race to embed generative AI into the standard electronic health record (EHR) ecosystem. By securing partnerships with major providers like Sutter Health, the company is positioning itself as a core infrastructure player rather than a standalone tool.

Physicians and clinical staff using integrated health systems may see expanded AI-driven search capabilities within their daily digital workflows. For patients, this suggests that medical providers have faster access to up-to-date peer-reviewed research during consultations.

The takeaway

The sustained venture interest in clinical AI demonstrates that medical professionals are increasingly shifting away from manual literature reviews in favor of automated synthesis. Users should verify that their health systems maintain rigorous privacy standards when integrating these external search tools into patient record platforms.