Researchers Studied Immune Cell Changes in Older People
The Malaghan Institute and University of Dundee are collaborating to improve vaccine effectiveness for older populations.
Updated on Oct. 10, 2026 in Senior Health
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The Malaghan Institute and the University of Dundee launched a research project to analyze how immune cells change with age. The study aims to understand why vaccines often show decreased effectiveness in older individuals.
Why it matters
Older people experience a decline in immune cell protein regulation, which hinders vaccine performance. Researchers hope these insights will lead to more effective vaccines that increase healthy longevity and reduce hospitalizations.
The project utilizes specialized technology from the University of Dundee to conduct an unbiased survey of proteins in rare immune cells collected from blood samples. It focuses on immune cell protein regulation declines in older populations.
The players
Malaghan Institute
This independent medical research institute is based in New Zealand and focuses on human health and immunology.
University of Dundee
Located in Scotland, this public research university provides the advanced technology necessary for analyzing proteins in small cell samples.
Rauawaawa Kaumātua Charitable Trust
Based in Hamilton, this organization works to engage with kaumātua, or Māori elders, to support this research initiative.
The details
Scientists are studying immune cells collected from older people following vaccination to identify specific functional changes. By utilizing new technology capable of surveying proteins in small cell numbers, the team aims to bridge the gap between protein levels and vaccine responses.
Timeline
October 10, 2026: The research collaboration was formally reported.
Health Landscape
This project aligns with ongoing global research initiatives targeting immunosenescence, the gradual deterioration of the immune system. It marks a shift toward precision proteomics to better understand how age-related protein regulation impacts vaccine efficacy.
This research may eventually lead to the development of more effective vaccines specifically optimized for the immune systems of older adults. Patients could see improved health outcomes and reduced rates of vaccine-preventable hospitalizations in the future.
The takeaway
Understanding the biological mechanisms of aging is essential for tailoring medical interventions to senior populations. Maintaining consistent vaccination schedules remains the most effective way for older adults to protect their health while this research progresses.
Further reading
For more on the current science regarding health as we age, visit the Senior Health section.
Source note: This article includes information reported by RNZ.
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