Researchers Identified Direct Cell-to-Cell DNA Transfer
Scientists found that damaged human cells can transmit genetic fragments, potentially spreading drug resistance.
Updated on Oct. 8, 2026 in Life Sciences
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Researchers have discovered a mechanism for the direct transfer of damaged genomic DNA between human cells through structures resembling tunneling nanotubes. These transferred DNA fragments persist within recipient cells and can confer antibiotic resistance.
Why it matters
The finding reveals a new dimension of genome instability heritability, suggesting that cells may share damaged genetic material to adapt to stressors. This mechanism is expected to influence how tumors develop resistance to therapies.
Researchers utilized a color-coded chromatin system with H2B-GFP and H2B-mCherry labeling to confirm DNA movement across 2 different epithelial cell types. Transferred genetic material is maintained as extrachromosomal elements.
The players
Maurais
Maurais is the lead researcher who directed the investigation into genome instability and intercellular DNA transfer.
The details
Using live-cell imaging, the study showed that genomic DNA moves through thin, tube-like connections between RPE1 cells. These extrachromosomal elements remain functional in the recipient, supporting gene expression and acquiring G418 antibiotic resistance.
Timeline
October 8, 2026: The study was published on nature.com.
The Big Picture
This discovery shifts the paradigm of genetic inheritance by demonstrating that cells can exchange damaged material directly. It challenges the traditional view of vertical inheritance, potentially unlocking new research into how genomic instability propagates.
This mechanism may lead to new medical treatments designed to block nanotube formation in cancer cells to prevent the spread of drug resistance. Future research could utilize these findings to improve the efficacy of existing therapies.
The takeaway
This discovery highlights that cells are not isolated units but active participants in shared genetic evolution. Understanding these communication channels could change how scientists approach drug-resistant conditions.
Further reading
Learn more about advancements in genetics in our Life Sciences section.
More information
Review the detailed findings in the scientific research study article.
Source note: This article includes information reported by Nature.
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