Beauty Brands Launched PDRN Oral Supplements
Major companies transitioned the skin repair ingredient from topical skincare into ingestible daily supplements.
Updated on Sept. 28, 2026 in Beauty
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In August 2026, beauty brands began expanding the use of Polydeoxyribonucleotide (PDRN) from traditional injectable skin therapies into new oral supplements. Companies like Amorepacific and Glowith Global introduced products containing the DNA-based ingredient to capture consumer interest in professional-grade aesthetic treatments.
Why it matters
Brands are leveraging established familiarity with PDRN-based aesthetic treatments to market new products that combine the ingredient with collagen. This strategic shift aims to address multiple skin health endpoints simultaneously through daily ingestible routines.
Amorepacific released a Vital Beautie liquid shot featuring 6,000 mg of collagen and a tablet with 100 mg of PDRN, while Glowith Global offers a liquid stick containing 150 mg of salmon-derived PDRN and 1,800 mg of marine collagen.
The players
Amorepacific
A South Korean beauty and cosmetics conglomerate that develops and markets various skincare and supplement brands.
Glowith Global
A wellness company that manufactures and distributes health-focused beauty supplements for the international market.
Italian Medicines Agency
The national regulatory body in Italy responsible for the authorization and monitoring of medicinal products.
The details
PDRN consists of DNA fragments sourced from salmon or microalgae that function through the nucleotide salvage pathway. To ensure efficacy in an oral format, manufacturers such as Amorepacific utilize controlled-release formulations designed to protect the active compounds within the gastrointestinal environment.
Timeline
1994: The Italian Medicines Agency granted the first approval for PDRN in medical skin therapies.
2014: A clinical study was published regarding the role of PDRN in healing diabetic foot ulcers.
August 2026: Amorepacific launched its PDRN-formulated Super Collagen supplement.
September 2026: Glowith Global debuted the HERAGEN liquid stick supplement at Vitafoods Asia.
Culture Shift
This transition marks a departure from the 1994 Italian Medicines Agency approval of PDRN for localized injections to broad-spectrum ingestible use. It reflects a wider movement where professional-grade aesthetic components move from medical clinics into the daily wellness routines of global consumers.
Consumers now have access to PDRN-based supplements that aim to simplify complex skin repair routines into daily intake. Shoppers should note that availability varies by region, with specific products like those from Glowith Global currently distributed through markets such as Watsons Malaysia.
The takeaway
The move to oral PDRN products highlights an attempt to replicate the results of clinical aesthetic procedures at home. As clinical studies on ingestible PDRN are still emerging, consumers should approach these new supplements as a developing category within the wider beauty market.
Further reading
Discover more about the evolving landscape of Beauty treatments and wellness trends.
Source note: This article includes information reported by NutraIngredients.
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